Science at the intersection of human immunology, metabolism, and critical illness.

We study how environmental and metabolic stress shape human immune function. Critical illness syndromes such as sepsis and ARDS expose immune cells to profound and rapidly changing physiological conditions, providing a powerful setting to investigate fundamental questions in human immunology. Our research draws on immune cells collected from ICU patients and a broad range of experimental techniques, including high-dimensional flow cytometry, single-cell transcriptomics, metabolomics, stable isotope tracing, metabolic flux analysis, and mechanistic experiments in primary human cells.

Our goal is to uncover fundamental principles of human immune regulation while advancing our understanding of immune dysfunction during critical illness. We are also committed to training the next generation of scientists and physician-scientists in a collaborative, supportive research environment.